Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain

FEBS Lett. 1998 Dec 28;441(3):392-6. doi: 10.1016/s0014-5793(98)01590-7.

Abstract

A longer variant of rat mRNA encoding the NR3 subunit of the NMDA receptor has been identified. It contains a 60-bp insertion at the nucleotide position 3007 in the intracellular domain of the C-terminal of the previously cloned variant. Therefore, the NR3 mRNA exists in at least two variants--with the insert (NR3-long; NR3-l) and without the insert (NR3-short; NR3-s). The NR3-l variant is expressed throughout the adult rat brain. Moreover, this variant predominates in the occipital and entorhinal cortices, thalamus and cerebellum. Analysis of NR3-l development indicates that it is regulated in a region-specific manner.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Brain / metabolism*
  • Cloning, Molecular
  • DNA, Complementary
  • Gene Expression Regulation, Developmental
  • Molecular Sequence Data
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • Rats
  • Receptors, N-Methyl-D-Aspartate / chemistry
  • Receptors, N-Methyl-D-Aspartate / genetics*
  • Receptors, N-Methyl-D-Aspartate / metabolism

Substances

  • DNA, Complementary
  • RNA, Messenger
  • Receptors, N-Methyl-D-Aspartate

Associated data

  • GENBANK/AF061945