(S)-4C3HPG reduces infarct size after focal cerebral ischemia

C Rauca; P Henrich-Noack; K Schäfer; V Höllt; K G Reymann

doi:10.1016/s0028-3908(98)00146-4

(S)-4C3HPG reduces infarct size after focal cerebral ischemia

Neuropharmacology. 1998 Dec;37(12):1649-52. doi: 10.1016/s0028-3908(98)00146-4.

Authors

C Rauca¹, P Henrich-Noack, K Schäfer, V Höllt, K G Reymann

Affiliation

¹ Institute of Pharmacology and Toxicology, Medical Faculty of Otto-von-Guericke University Magdeburg, Germany. ipt@uni-magdeburg.de

PMID: 9886689
DOI: 10.1016/s0028-3908(98)00146-4

Abstract

This study investigated whether the metabotropic glutamate receptor ligand (S)-4C3HPG can reduce brain damage after focal ischemia in rats. Application of 1 micromol of (S)-4C3HPG (intracerebroventricularly) 5 min after occlusion of the middle cerebral artery significantly reduced the infarct size by 72.3% of the saline control.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cerebral Infarction / etiology
Cerebral Infarction / prevention & control*
Cerebral Ventricles / drug effects
Cerebral Ventricles / physiology
Cerebral Ventricles / physiopathology
Glycine / administration & dosage
Glycine / analogs & derivatives*
Glycine / pharmacology
Injections, Intraventricular
Ischemic Attack, Transient / drug therapy*
Ischemic Attack, Transient / physiopathology
Male
Neuroprotective Agents / administration & dosage
Neuroprotective Agents / pharmacology*
Rats
Rats, Wistar

Substances

Neuroprotective Agents
4-carboxy-3-hydroxyphenylglycine
Glycine