Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa

MeSH terms

• Administration, Oral
• Amidines / chemical synthesis*
• Amidines / chemistry
• Amidines / pharmacokinetics
• Amidines / pharmacology
• Animals
• Anticoagulants / chemical synthesis*
• Anticoagulants / chemistry
• Anticoagulants / pharmacokinetics
• Anticoagulants / pharmacology
• Benzylidene Compounds / chemical synthesis
• Benzylidene Compounds / chemistry
• Benzylidene Compounds / pharmacokinetics
• Benzylidene Compounds / pharmacology
• Binding Sites
• Biological Availability
• Cattle
• Crystallography, X-Ray
• Dogs
• Drug Evaluation, Preclinical
• Factor Xa Inhibitors*
• Humans
• Injections, Intravenous
• Macaca fascicularis
• Models, Molecular
• Molecular Conformation
• Papio
• Pyridines / chemical synthesis*
• Pyridines / chemistry
• Pyridines / pharmacokinetics
• Pyridines / pharmacology
• Serine Proteinase Inhibitors / chemical synthesis*
• Serine Proteinase Inhibitors / chemistry
• Serine Proteinase Inhibitors / pharmacokinetics
• Serine Proteinase Inhibitors / pharmacology
• Stereoisomerism
• Structure-Activity Relationship
• Thrombin / antagonists & inhibitors
• Trypsin Inhibitors / chemical synthesis
• Trypsin Inhibitors / chemistry
• Trypsin Inhibitors / pharmacokinetics
• Trypsin Inhibitors / pharmacology