Abstract
The antiplatelet and antithrombotic effects of the oral combination treatment of ticlopidine and Ginkgo biloba extract (EGb 761) were studied in normal and thrombosis-induced rats. The ex vivo inhibitory effect on ADP-induced platelet aggregation of a small dose of ticlopidine (50 mg/kg/day) in combination with EGb 761 (40 mg/kg/day) was comparable to a larger dose of only ticlopidine (200 mg/kg/day). Bleeding time was also prolonged by 150%. Thrombus weight was also consistently decreased by a combination of ticlopidine and EGb 761 in an arterio-venous shunt model at two doses of ticlopidine (50 mg/kg) plus EGb 761 (20 mg/kg) and ticlopidine (50 mg/kg) plus EGb 761 (40 mg/kg). A combinatory treatment in acute thrombosis model in mice also showed a higher recovery than a single treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Platelets / drug effects*
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Collagen / pharmacology
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Dose-Response Relationship, Drug
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Drug Interactions
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Epinephrine / pharmacology
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Fibrinolytic Agents / pharmacology*
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Flavonoids / administration & dosage
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Flavonoids / pharmacology*
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Ginkgo biloba
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Hemostatics / administration & dosage
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Hemostatics / pharmacology*
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Mice
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Plant Extracts*
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / administration & dosage
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Platelet Aggregation Inhibitors / pharmacology*
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Rats
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Thrombosis / chemically induced
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Ticlopidine / administration & dosage
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Ticlopidine / pharmacology*
Substances
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Fibrinolytic Agents
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Flavonoids
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Hemostatics
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Plant Extracts
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Platelet Aggregation Inhibitors
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Ginkgo biloba extract
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Collagen
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Ticlopidine
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Epinephrine