Abstract
The role of the alpha-1 adrenoceptor in prepulse inhibition (PPI) was evaluated in rats. The alpha-1 adrenergic agonist cirazoline disrupted PPI; this effect was reversed by the alpha-1 adrenergic antagonist prazosin or the atypical antipsychotic quetiapine. Alpha-1 adrenoceptors may thus be involved in the regulation of PPI and in the psychotherapeutic actions of certain antipsychotics.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenergic alpha-Agonists / pharmacology*
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Animals
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Dibenzothiazepines / pharmacology
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Dopamine Antagonists / pharmacology
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Imidazoles / pharmacology*
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Male
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Prazosin / pharmacology
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Quetiapine Fumarate
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Raclopride
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Rats
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Rats, Sprague-Dawley
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Receptors, Adrenergic, alpha-1 / drug effects*
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Receptors, Adrenergic, alpha-1 / physiology
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Reflex, Startle / drug effects*
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Reflex, Startle / physiology
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Salicylamides / pharmacology
Substances
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Adrenergic alpha-Agonists
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Dibenzothiazepines
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Dopamine Antagonists
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Imidazoles
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Receptors, Adrenergic, alpha-1
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Salicylamides
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Quetiapine Fumarate
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Raclopride
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cirazoline
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Prazosin