Abstract
Delta9-tetrahydrocannabinol (delta9-THC), cannabinol and cannabidiol are three important natural cannabinoids from the Marijuana plant (Cannabis sativa). Using [35S]GTP-gamma-S binding on rat cerebellar homogenate as an index of cannabinoid receptor activation we show that: delta9-THC does not induce the maximal effect obtained by classical cannabinoid receptor agonists such as CP55940. Moreover at high concentration delta9-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range.
MeSH terms
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Analgesics / pharmacology
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Animals
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Binding, Competitive / drug effects
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Brain / drug effects*
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Brain / metabolism
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Cannabidiol / pharmacology*
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Cell Membrane / drug effects
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Cell Membrane / metabolism
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Cerebellar Cortex / drug effects
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Cyclohexanols / pharmacology
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Dronabinol / pharmacology*
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Guanosine Triphosphate / metabolism
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Male
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Piperidines / pharmacology
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Pyrazoles / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Cannabinoid
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Receptors, Drug / agonists*
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Receptors, Drug / antagonists & inhibitors*
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Receptors, Drug / metabolism
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Rimonabant
Substances
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Analgesics
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Cyclohexanols
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Piperidines
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Pyrazoles
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Receptors, Cannabinoid
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Receptors, Drug
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Cannabidiol
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Dronabinol
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3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
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Guanosine Triphosphate
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Rimonabant