Abstract
The role of mu-opioid receptor in gastrointestinal transit was investigated using mu-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a mu-opioid receptor mediated function. In addition, we show that neither delta nor kappa receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (+/-) and wild type (+/+) animals.
Copyright 1998 Elsevier Science B.V.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer / administration & dosage
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Animals
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Enkephalin, D-Penicillamine (2,5)-
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Enkephalins / administration & dosage
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Gastrointestinal Transit / drug effects
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Gastrointestinal Transit / genetics*
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Injections, Intraventricular
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Injections, Subcutaneous
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Male
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Mice
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Mice, Knockout
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Morphine / administration & dosage
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Receptors, Opioid, mu / genetics*
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Receptors, Opioid, mu / physiology*
Substances
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Enkephalins
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Receptors, Opioid, mu
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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
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Morphine
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Enkephalin, D-Penicillamine (2,5)-