4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist

J Med Chem. 1998 Apr 9;41(8):1205-8. doi: 10.1021/jm980053f.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Adrenergic alpha-1 Receptor Antagonists*
  • Adrenergic alpha-Antagonists / chemical synthesis
  • Adrenergic alpha-Antagonists / chemistry
  • Adrenergic alpha-Antagonists / metabolism
  • Adrenergic alpha-Antagonists / pharmacology*
  • Animals
  • Antihypertensive Agents / chemical synthesis
  • Antihypertensive Agents / chemistry
  • Antihypertensive Agents / pharmacology
  • Blood Pressure / drug effects
  • Humans
  • Male
  • Organ Specificity
  • Prazosin / analogs & derivatives*
  • Prazosin / chemical synthesis
  • Prazosin / chemistry
  • Prazosin / metabolism
  • Prazosin / pharmacology
  • Rats
  • Rats, Inbred SHR
  • Rats, Sprague-Dawley
  • Receptors, Adrenergic, alpha-1 / metabolism
  • Spinal Cord / metabolism
  • Structure-Activity Relationship

Substances

  • ADRA1B protein, human
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Antihypertensive Agents
  • L 765314
  • Receptors, Adrenergic, alpha-1
  • Terazosin
  • Prazosin