Abstract
The alpha7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha7 receptors appear neuroprotective in non-apoptotic model.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Benzylidene Compounds / pharmacology
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Excitatory Amino Acid Antagonists / pharmacology*
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Ischemic Attack, Transient / prevention & control*
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Male
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Neurons / drug effects*
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Neuroprotective Agents / pharmacology*
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Nicotinic Agonists / pharmacology*
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Pyridines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Nicotinic / physiology*
Substances
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Benzylidene Compounds
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Excitatory Amino Acid Antagonists
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Neuroprotective Agents
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Nicotinic Agonists
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Pyridines
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Receptors, Nicotinic
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3-(2,4-dimethoxybenzylidene)anabaseine