Abstract
The activity and regional distribution of D-amino acid oxidase (DAO), an enzyme that inactivates D-serine, were examined in the medulla and spinal cord of the rat by biochemical and histochemical procedures. DAO activity was noticeably low or absent in the nucleus of the solitary tract, ventrolateral medulla and intramediolateral cell column of the spinal cord. This may be indicative of a neuromodulatory role for endogenous D-serine (at the NMDA-glycine site) in in the central control of blood pressure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Oxidoreductases / antagonists & inhibitors
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Amino Acid Oxidoreductases / metabolism*
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Animals
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Autonomic Nervous System / drug effects
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Autonomic Nervous System / enzymology*
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Autonomic Nervous System / physiology*
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Brain / enzymology
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Male
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Medulla Oblongata / drug effects
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Medulla Oblongata / enzymology*
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Microinjections
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Rats
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Rats, Inbred SHR
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Rats, Inbred WKY
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Serine / administration & dosage
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Serine / pharmacology*
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Spinal Cord / drug effects
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Spinal Cord / enzymology*
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Spinal Cord / physiology*
Substances
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Serine
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Amino Acid Oxidoreductases