Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

P J Meier; U Eckhardt; A Schroeder; B Hagenbuch; B Stieger

doi:10.1002/hep.510260641

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

Hepatology. 1997 Dec;26(6):1667-77. doi: 10.1002/hep.510260641.

Authors

P J Meier¹, U Eckhardt, A Schroeder, B Hagenbuch, B Stieger

Affiliation

¹ Department of Medicine, University Hospital, Zürich, Switzerland.

PMID: 9398014
DOI: 10.1002/hep.510260641

Abstract

The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Anion Transport Proteins
Anions / metabolism
Bile Acids and Salts / metabolism
Bile Acids and Salts / physiology
Carrier Proteins / genetics
Carrier Proteins / physiology*
Cloning, Molecular
Humans
Liver / metabolism*
Membrane Transport Proteins*
Models, Molecular
Organic Anion Transporters, Sodium-Dependent
Rats
Substrate Specificity
Symporters

Substances

Anion Transport Proteins
Anions
Bile Acids and Salts
Carrier Proteins
Membrane Transport Proteins
Organic Anion Transporters, Sodium-Dependent
Symporters
sodium-bile acid cotransporter