Abstract
We investigated the effects of isoliquiritigenin and YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole) on tension in endothelial-free rat aortic rings precontracted with phenylephrine (3 microM). Both compounds induced a concentration-dependent relaxation (EC50 of YC-1 1.9 microM and of isoliquiritigenin 9.4 microM). The effects developed faster with YC-1 than with isoliquiritigenin, and the effects of YC-1 were potentiated by isoliquiritigenin (10 microM). 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (30 microM) inhibited the effect of YC-1, but not of isoliquiritigenin. These results suggest that the effects of YC-1 are due to stimulation of soluble guanylyl cyclase activity, whereas the effects of isoliquiritigenin are rather related to inhibition of phosphodiesterase activity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aldehyde Reductase / antagonists & inhibitors*
-
Animals
-
Carotid Arteries / drug effects
-
Carotid Arteries / metabolism
-
Chalcone / analogs & derivatives*
-
Chalcone / pharmacology
-
Chalcones
-
Dose-Response Relationship, Drug
-
Enzyme Inhibitors / pharmacology*
-
Female
-
Guanylate Cyclase / metabolism
-
Indazoles / pharmacology*
-
Male
-
Muscle Contraction / drug effects
-
Muscle Relaxation / drug effects
-
Muscle, Smooth, Vascular / drug effects*
-
Phosphodiesterase Inhibitors / pharmacology
-
Platelet Aggregation Inhibitors / pharmacology*
-
Rats
-
Rats, Sprague-Dawley
Substances
-
Chalcones
-
Enzyme Inhibitors
-
Indazoles
-
Phosphodiesterase Inhibitors
-
Platelet Aggregation Inhibitors
-
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
-
Chalcone
-
isoliquiritigenin
-
Aldehyde Reductase
-
Guanylate Cyclase