Abstract
Antagonists of the N-methyl-D-Aspartate (NMDA) subtype of glutamate receptor (e.g., phencyclidine, ketamine, MK-801) cause a schizophrenia-like psychosis in humans and neurotoxicity in the adult rat brain. We report here that clozapine and structurally related agents (olanzapine, fluperlapine, loxapine, amoxapine) can prevent NMDA antagonist neurotoxicity in the rat with a rank order corresponding to their ability to mimic the antipsychotic properties of clozapine.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antipsychotic Agents / pharmacology*
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Benzodiazepines
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Clozapine / pharmacology
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Dibenzazepines / pharmacology*
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Dibenzoxazepines / pharmacology
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Dizocilpine Maleate / adverse effects
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Dizocilpine Maleate / antagonists & inhibitors*
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Female
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N-Methylaspartate / antagonists & inhibitors
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Nervous System / drug effects
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Olanzapine
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Pirenzepine / analogs & derivatives*
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Pirenzepine / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
Substances
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Antipsychotic Agents
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Dibenzazepines
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Dibenzoxazepines
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Receptors, N-Methyl-D-Aspartate
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Benzodiazepines
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Pirenzepine
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N-Methylaspartate
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Dizocilpine Maleate
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fluperlapine
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Clozapine
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Olanzapine