Abstract
The NF-kappa B/Rel family of transcription factors participates in the activation of a diverse range of genes involved in inflammation, immune response, lymphoid differentiation, growth control and development. The present review provides a brief overview of NF-kappa B/Rel activation and a detailed analysis of important biological and biochemical inhibitors of the NF-kappa B/Rel pathway. Given the pleiotropic role of NF-kappa B in controlling cytokines and other immunoregulatory genes, the inhibition of NF-kappa B activation by steroid hormones, antioxidants, protease inhibitors and other compounds may provide a pharmacological basis for interfering with pathological inflammatory conditions, cancer and AIDS.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antioxidants / pharmacology
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Aspirin / pharmacology
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Cyclosporine / pharmacology
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Cytokines / biosynthesis*
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Cytokines / drug effects
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Dinoprostone / pharmacology
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Forecasting
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Glucocorticoids / pharmacology
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Humans
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Immunosuppressive Agents / pharmacology
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Mutation
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NF-kappa B / antagonists & inhibitors*
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NF-kappa B / metabolism*
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Nitric Oxide / metabolism
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Oncogene Proteins v-rel
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Phosphorylation / drug effects
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Protease Inhibitors / pharmacology
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Proto-Oncogene Proteins / drug effects
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism
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Retroviridae Proteins, Oncogenic / drug effects*
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Retroviridae Proteins, Oncogenic / metabolism*
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Tacrolimus / pharmacology
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Transcription Factor RelB
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Transcription Factors*
Substances
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Antioxidants
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Cytokines
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Glucocorticoids
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Immunosuppressive Agents
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NF-kappa B
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Oncogene Proteins v-rel
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Protease Inhibitors
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Proto-Oncogene Proteins
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RELB protein, human
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Retroviridae Proteins, Oncogenic
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Transcription Factors
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Transcription Factor RelB
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Nitric Oxide
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Cyclosporine
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Dinoprostone
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Aspirin
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Tacrolimus