Abstract
An unbiased conditioned place preference procedure was used to determine whether the newly-identified neuropeptide orphanin FQ produced motivational effects after intracerebroventricular microinjections. Microinjections of orphanin FQ (0.1-100 nmol) failed to produce conditioned place preference or aversion, but a pronounced motor impairment was observed during conditioning sessions with the two highest doses. Thus, it appears that orphanin FQ lacks motivational effects when administered at behaviourally active doses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cerebral Ventricles / drug effects
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Cerebral Ventricles / physiology*
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Conditioning, Operant / drug effects
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Conditioning, Operant / physiology*
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Dose-Response Relationship, Drug
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Injections, Intraventricular
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Male
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Microinjections
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Morphine / pharmacology
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Motivation
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Motor Activity / drug effects
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Naloxone / pharmacology
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Narcotic Antagonists
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Nociceptin
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Opioid Peptides / administration & dosage
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Opioid Peptides / pharmacology*
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Rats
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Rats, Sprague-Dawley
Substances
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Narcotic Antagonists
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Opioid Peptides
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Naloxone
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Morphine