Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: implications for diazepam disposition in humans

J Clin Psychopharmacol. 1996 Aug;16(4):267-72. doi: 10.1097/00004714-199608000-00001.
No abstract available

Publication types

  • Comparative Study
  • Editorial

MeSH terms

  • Aryl Hydrocarbon Hydroxylases*
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / metabolism*
  • Diazepam / pharmacokinetics*
  • Humans
  • Isoenzymes / metabolism*
  • Liver / metabolism
  • Metabolic Clearance Rate
  • Mixed Function Oxygenases / metabolism*

Substances

  • Isoenzymes
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C19 protein, human
  • CYP3A protein, human
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP3A
  • Diazepam