Abstract
Plasma albumin reacts with nitric oxide (NO) to form S-nitroso-albumin (albumin-S-NO). The present study was designed to elucidate whether NO-induced response on blood pressure may differ between analbuminemic rats (NAR) and normal rats. When NOC7, a NO donor, was intravenously injected in rats, blood pressure decreased and the initial depressor response was the same in both the NAR and the normal rats. However, the duration of NO-induced hypotension was 0.5 times longer in NAR than in the normal rat. After NOC7 injection, plasma thiol levels decreased and S-nitrosothiols levels increased in the normal rats, whereas these levels slightly changed in NAR. These results suggested that NO reacts with albumin-SH, resulting in albumin-S-NO formation, which produces a continuous hypotensive response in blood pressure as a slow releaser of NO.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Pressure / drug effects
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Glutathione / analogs & derivatives
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Glutathione / blood
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Homeostasis
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Injections, Intravenous
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Male
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Muscle Tonus / physiology*
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / physiology*
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Nitric Oxide / pharmacology
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Nitric Oxide / physiology*
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Nitroso Compounds / blood
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Papaverine / pharmacology
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Rats
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Rats, Mutant Strains
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Rats, Wistar
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Reference Values
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S-Nitrosoglutathione
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Serum Albumin / deficiency
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Serum Albumin / physiology*
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Serum Albumin, Bovine / metabolism
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Sulfhydryl Compounds / blood
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Time Factors
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Triazenes / pharmacology
Substances
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(1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl-3-aminopropyl)-3-methyl-1-triazene
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Nitroso Compounds
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S-nitrosoalbumin
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Serum Albumin
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Sulfhydryl Compounds
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Triazenes
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Serum Albumin, Bovine
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Nitric Oxide
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S-Nitrosoglutathione
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Papaverine
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Glutathione