2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor

J Med Chem. 1996 Jun 7;39(12):2281-4. doi: 10.1021/jm9602423.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Binding, Competitive
  • CHO Cells
  • Ciliary Body / drug effects
  • Cricetinae
  • Cricetulus
  • Drug Design
  • Guinea Pigs
  • Humans
  • Muscle Contraction / drug effects
  • Peptide Fragments / antagonists & inhibitors
  • Piperidines / chemistry
  • Piperidines / pharmacology
  • Quinolines / chemistry
  • Quinolines / classification
  • Quinolines / pharmacology*
  • Rabbits
  • Receptors, Neurokinin-3 / antagonists & inhibitors*
  • Recombinant Fusion Proteins / antagonists & inhibitors
  • Structure-Activity Relationship
  • Substance P / analogs & derivatives
  • Substance P / antagonists & inhibitors

Substances

  • Peptide Fragments
  • Piperidines
  • Quinolines
  • Receptors, Neurokinin-3
  • Recombinant Fusion Proteins
  • senktide
  • Substance P
  • SR 142801