Abstract
Tolerance to delta 9-tetrahydrocannabinol (delta 9-THC) was produced in rats by twice daily injections (15 mg/kg i.p.) for 6.5 days. Administration of the cannabinoid antagonist SR141716A (i.p. or i.c.v.) induced a profound precipitated withdrawal syndrome in delta 9-THC-tolerant animals. The syndrome was characterized by a disorganized pattern of constantly changing brief sequences of motor behavior. Autonomic signs were not evident. THC-tolerant animals that were treated with vehicle remained quiet throughout the observation period.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Dronabinol / administration & dosage
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Dronabinol / adverse effects*
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Hallucinogens / administration & dosage
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Hallucinogens / adverse effects*
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Injections, Intraperitoneal
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Motor Activity / drug effects
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Piperidines / administration & dosage
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Piperidines / pharmacology*
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Pyrazoles / administration & dosage
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Pyrazoles / pharmacology*
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Rats
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Receptors, Cannabinoid
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Receptors, Drug / antagonists & inhibitors*
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Rimonabant
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Substance Withdrawal Syndrome / etiology*
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Substance Withdrawal Syndrome / physiopathology
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Vocalization, Animal / drug effects
Substances
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Hallucinogens
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Piperidines
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Pyrazoles
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Receptors, Cannabinoid
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Receptors, Drug
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Dronabinol
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Rimonabant