Are bacterial proteinases pathogenic factors?

Trends Microbiol. 1995 Oct;3(10):405-7. doi: 10.1016/s0966-842x(00)88988-x.

Abstract

Evidence is rapidly accumulating that suggests that the growth and proliferation of pathogenic bacteria depend on proteolytic enzymes of the invading organism and of the host. Proteinase inhibitors targeting bacterial proteinases may be useful antimicrobial agents.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / enzymology*
  • Bacteria / pathogenicity
  • Bacterial Infections / drug therapy
  • Bacterial Infections / microbiology
  • Bacterial Proteins / drug effects
  • Bacterial Proteins / physiology*
  • Endopeptidases / drug effects
  • Endopeptidases / physiology*
  • Humans
  • Kallikreins / metabolism
  • Kinins / metabolism
  • Protease Inhibitors / therapeutic use
  • Virulence

Substances

  • Bacterial Proteins
  • Kinins
  • Protease Inhibitors
  • Endopeptidases
  • Kallikreins