Abstract
This double-blind placebo-controlled treatment study tested the efficacy of mazindol in currently cocaine-dependent out-patients. Forty-three patients were randomized to mazindol (2 mg QD) vs. placebo treatment for 6 weeks. All patients received weekly group counseling. Patients improved with respect to objective (urine toxicology) and subjective (self-report of times used, dollars spent, craving, etc.) measures. There was no response difference between patients treated with mazindol and those who received placebo.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Central Nervous System Stimulants / adverse effects
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Central Nervous System Stimulants / therapeutic use*
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Cocaine* / adverse effects
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Double-Blind Method
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Female
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Humans
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Male
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Mazindol / adverse effects
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Mazindol / therapeutic use*
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Neurologic Examination / drug effects
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Substance Abuse Detection
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Substance Withdrawal Syndrome / rehabilitation
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Substance-Related Disorders / rehabilitation*
Substances
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Central Nervous System Stimulants
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Mazindol
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Cocaine