N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist

J Med Chem. 1993 Apr 16;36(8):1104-7. doi: 10.1021/jm00060a019.

Authors

I T Forbes¹, G A Kennett, A Gadre, P Ham, C J Hayward, R T Martin, M Thompson, M D Wood, G S Baxter, A Glen, et al.

Affiliation

¹ Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex, England.

PMID: 8478907
DOI: 10.1021/jm00060a019

No abstract available

MeSH terms

Animals
Binding Sites
Brain / drug effects
Brain / metabolism
Guinea Pigs
Humans
Indoles / chemical synthesis*
Indoles / metabolism
Indoles / pharmacology
Male
Rats
Rats, Sprague-Dawley
Receptors, Serotonin / metabolism
Serotonin Antagonists*
Structure-Activity Relationship
Urea / analogs & derivatives*
Urea / chemical synthesis
Urea / metabolism
Urea / pharmacology

Substances

Indoles
Receptors, Serotonin
Serotonin Antagonists
N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea
Urea