Abstract
The influence of adrenalectomy on cannabinoid receptor gene expression in the adult rat dorsal striatum was investigated by in situ hybridization with specific oligonucleotide probes. The caudate-putamen of adrenalectomized rats contains approximately 50% significantly higher mRNA levels than the controls. This increase could be counteracted by dexamethasone treatment. Together, these results suggest glucocorticoid down-regulation of cannabinoid receptor gene expression in the striatum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenalectomy*
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Animals
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Caudate Nucleus / drug effects
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Caudate Nucleus / metabolism*
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Dexamethasone / pharmacology*
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Down-Regulation
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Enkephalins / biosynthesis
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In Situ Hybridization
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Male
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Oligonucleotide Probes
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Protein Precursors / biosynthesis
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Putamen / drug effects
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Putamen / metabolism*
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RNA, Messenger / metabolism*
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Rats
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Rats, Wistar
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Receptors, Cannabinoid
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Receptors, Drug / biosynthesis*
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Receptors, Drug / drug effects
Substances
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Enkephalins
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Oligonucleotide Probes
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Protein Precursors
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RNA, Messenger
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Receptors, Cannabinoid
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Receptors, Drug
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proenkephalin
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Dexamethasone