Glucocorticoid regulation of cannabinoid receptor messenger RNA levels in the rat caudate-putamen. An in situ hybridization study

Neurosci Lett. 1993 Jun 25;156(1-2):51-3. doi: 10.1016/0304-3940(93)90437-p.

Abstract

The influence of adrenalectomy on cannabinoid receptor gene expression in the adult rat dorsal striatum was investigated by in situ hybridization with specific oligonucleotide probes. The caudate-putamen of adrenalectomized rats contains approximately 50% significantly higher mRNA levels than the controls. This increase could be counteracted by dexamethasone treatment. Together, these results suggest glucocorticoid down-regulation of cannabinoid receptor gene expression in the striatum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenalectomy*
  • Animals
  • Caudate Nucleus / drug effects
  • Caudate Nucleus / metabolism*
  • Dexamethasone / pharmacology*
  • Down-Regulation
  • Enkephalins / biosynthesis
  • In Situ Hybridization
  • Male
  • Oligonucleotide Probes
  • Protein Precursors / biosynthesis
  • Putamen / drug effects
  • Putamen / metabolism*
  • RNA, Messenger / metabolism*
  • Rats
  • Rats, Wistar
  • Receptors, Cannabinoid
  • Receptors, Drug / biosynthesis*
  • Receptors, Drug / drug effects

Substances

  • Enkephalins
  • Oligonucleotide Probes
  • Protein Precursors
  • RNA, Messenger
  • Receptors, Cannabinoid
  • Receptors, Drug
  • proenkephalin
  • Dexamethasone