Abstract
Two phenylglycine derivates, (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine, competitively antagonised (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD)-stimulated phosphoinositide hydrolysis in rat cerebral cortical slices. The same phenylglycine derivatives selectively antagonized ACPD-induced depolarization in neonatal rat spinal motoneurones and rate thalamic neurones relative to depolarization or excitation induced by N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). Both phenylglycine derivatives also selectively depressed synaptic excitation in thalamic neurones evoked by noxious thermal stimuli, without affecting the synaptic stimulation of the same cells by non-noxious stimuli.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Newborn
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Benzoates / pharmacology*
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Cerebral Cortex / drug effects
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Cerebral Cortex / metabolism
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Chromatography, High Pressure Liquid
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Cycloleucine / analogs & derivatives
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Cycloleucine / antagonists & inhibitors
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Cycloleucine / pharmacology
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Excitatory Amino Acid Antagonists*
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Glycine / analogs & derivatives*
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Glycine / pharmacology
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In Vitro Techniques
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Motor Neurons / drug effects
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N-Methylaspartate / pharmacology
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Phosphatidylinositols / metabolism
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Rats
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Spinal Cord / cytology
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Spinal Cord / drug effects
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Synapses / drug effects
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Thalamus / cytology
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Thalamus / drug effects
Substances
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Benzoates
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Excitatory Amino Acid Antagonists
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Phosphatidylinositols
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Cycloleucine
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1-amino-1,3-dicarboxycyclopentane
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alpha-methyl-4-carboxyphenylglycine
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N-Methylaspartate
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4-carboxyphenylglycine
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Glycine