Abstract
The effect of repetitive administration of delta-9-tetrahydrocannabinol (delta 9-THC) in mice on behavioral and biochemical tolerance was determined in this study. Mice were injected twice daily with 10 mg/kg delta 9-THC for 6.5 days. On day 8, spontaneous activity was assessed or whole-brain homogenates were prepared for the cannabinoid receptor binding and mRNA studies. Although a twenty-sevenfold tolerance to delta 9-THC was observed in the behavioral assay, there was no significant alteration in receptor binding or mRNA levels.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Behavior, Animal / drug effects*
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Blotting, Northern
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Brain Chemistry / drug effects*
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Cyclohexanols / pharmacology
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DNA Probes
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Dronabinol / pharmacology*
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Drug Tolerance
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Electrophoresis, Polyacrylamide Gel
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In Situ Hybridization
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In Vitro Techniques
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Male
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Membranes / drug effects
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Membranes / metabolism
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Mice
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Mice, Inbred ICR
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RNA, Messenger / biosynthesis*
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Receptors, Cannabinoid
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Receptors, Drug / drug effects*
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Receptors, Drug / metabolism
Substances
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Cyclohexanols
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DNA Probes
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RNA, Messenger
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Receptors, Cannabinoid
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Receptors, Drug
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Dronabinol
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3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol