Abstract
The pentameric subunit composition of a large population (36%) of the cerebellar granule cell GABAA receptors that show diazepam (or clonazepam)-insensitive [3H]Ro 15-4513 binding has been determined by immunoprecipitation with subunit-specific antibodies. These receptors have alpha 6, alpha 1, gamma 2S, gamma 2L, and beta 2 or beta 3 subunits colocalizing in the same receptor complex.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies / analysis
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Antibodies / immunology
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Cerebellum / chemistry*
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Cerebellum / cytology
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Cerebellum / ultrastructure
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Diazepam / pharmacology
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Molecular Sequence Data
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Precipitin Tests
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Rats
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Receptors, GABA-A / analysis*
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Receptors, GABA-A / chemistry
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Receptors, GABA-A / immunology
Substances
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Antibodies
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Receptors, GABA-A
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Diazepam