Abstract
Inhibition of tumour promotion by various vitamin E compounds (tocopherols and tocotrienols) and some of their dimers was examined by an in vitro assay utilizing the activation of Epstein-Barr virus (EBV) early antigen (EA) expression in EBV-genome-carrying human lymphoblastoid cells. The results reveal that gamma- and delta-tocotrienols derived from palm oil exhibit a strong activity against tumour promotion by inhibiting EBV EA expression in Raji cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). However, alpha- and gamma-tocopherols and dimers of gamma-tocotrienol or gamma-tocopherol lack this activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticarcinogenic Agents / therapeutic use*
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Antigens, Viral / physiology
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Butyrates
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Butyric Acid
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Cell Transformation, Viral / drug effects
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Genome, Viral
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Herpesvirus 4, Human / genetics
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Humans
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Lymphocytes / drug effects
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Lymphocytes / microbiology
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Neoplasms / chemically induced
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Neoplasms / prevention & control*
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Palm Oil
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Plant Oils / therapeutic use*
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Tetradecanoylphorbol Acetate
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Tumor Cells, Cultured
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Vitamin E / therapeutic use*
Substances
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Anticarcinogenic Agents
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Antigens, Viral
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Butyrates
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Epstein-Barr virus early antigen
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Plant Oils
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Butyric Acid
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Vitamin E
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Palm Oil
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Tetradecanoylphorbol Acetate