Abstract
Acute injections of the full dopamine D1 receptor agonist A-77636 ((1R,3S)-3-(1'adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1 H-2-benzopyran hydrochloride) induce ipsilateral Fos-like immunoreactivity and contralateral rotation into rats bearing unilateral dopamine depleting lesions. However, following repeated treatment, A-77636 fails to induce either striatal c-fos or rotation. Our results suggest that striatal c-fos activation mirrors behavioral indices of dopamine D1 receptor sensitivity.
MeSH terms
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Adamantane / analogs & derivatives*
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Adamantane / pharmacology
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Animals
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Benzopyrans / pharmacology*
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Corpus Striatum / drug effects*
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Corpus Striatum / metabolism
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Dopamine Agents / pharmacology*
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Drug Tolerance
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Gene Expression Regulation / drug effects
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Genes, fos
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Male
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Motor Activity / drug effects*
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Proto-Oncogene Proteins c-fos / biosynthesis*
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Rats
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Rats, Sprague-Dawley
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Receptors, Dopamine D1 / metabolism
Substances
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Benzopyrans
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Dopamine Agents
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Proto-Oncogene Proteins c-fos
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Receptors, Dopamine D1
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A 77636
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Adamantane