Abstract
Rats initiated to self-administer 10% ethanol (v/v) in an operant situation using the sucrose-substitution technique received bilateral n. accumbens or caudate nucleus microinjections of d-amphetamine (4, 10, and 20 micrograms/brain), quinpirole (4 micrograms/brain), and/or raclopride (0.1, 0.5, and 1.0 micrograms/brain). Only microinjections into the n. accumbens produced changes in rate and pattern of responding. With d-amphetamine, an increase in total responding and a slowing of initial response rate was seen, whereas with raclopride administration a dose-related decrease in total responding was observed with no alteration in momentary response rates. Drug-dependent behavioral rate and pattern differences suggest that DA activity in the n. accumbens influences ethanol reinforced behavior.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Analysis of Variance
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Animals
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Caudate Nucleus / drug effects
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Caudate Nucleus / physiology*
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Conditioning, Operant
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Dextroamphetamine / administration & dosage
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Dextroamphetamine / pharmacology*
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Dopamine Agents / pharmacology*
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Dopamine D2 Receptor Antagonists*
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Dose-Response Relationship, Drug
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Ergolines / administration & dosage
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Ergolines / pharmacology*
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Ethanol / administration & dosage
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Ethanol / pharmacology*
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Male
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Microinjections
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / physiology*
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Quinpirole
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Raclopride
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Rats
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Reinforcement, Psychology*
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Salicylamides / administration & dosage
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Salicylamides / pharmacology*
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Self Administration
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Sucrose / pharmacology
Substances
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Dopamine Agents
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Dopamine D2 Receptor Antagonists
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Ergolines
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Salicylamides
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Quinpirole
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Ethanol
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Raclopride
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Sucrose
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Dextroamphetamine