Abstract
Oxidative modification of low-density lipoprotein (LDL) may be atherogenic. We studied the time of onset of LDL oxidation (lag) in 18 postmenopausal women before and after intraarterial infusion of 17 beta-oestradiol, after 3 weeks' patch administration in 12 of these women, and 1 month after discontinuation in 10. The lag increased from baseline after acute infusion (from 134 [SD41] to 167 [36] min, p = 0.01) and after the patch (132 [31] to 178 [45] min, p = 0.009). After discontinuation of oestradiol, the lag returned to baseline. This study shows an antioxidant effect of physiological levels of 17 beta-oestradiol, which may contribute to an anti-atherogenic action.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Administration, Cutaneous
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Antioxidants / analysis
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Antioxidants / pharmacology*
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Arteriosclerosis / blood
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Arteriosclerosis / drug therapy
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Arteriosclerosis / etiology
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Cholesterol / blood
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Cholesterol, HDL / blood
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Cholesterol, LDL / blood
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Estradiol / blood
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Estradiol / pharmacology*
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Estrogen Replacement Therapy / methods*
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Female
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Humans
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Infusions, Intra-Arterial
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Lipid Peroxidation / drug effects*
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Lipoproteins, LDL / blood
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Lipoproteins, LDL / drug effects*
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Middle Aged
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Postmenopause / blood
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Postmenopause / drug effects*
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Time Factors
Substances
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Antioxidants
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Cholesterol, HDL
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Cholesterol, LDL
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Lipoproteins, LDL
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Estradiol
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Cholesterol