Expression and selective inhibition of constitutive and inducible forms of cyclooxygenase

Adv Prostaglandin Thromboxane Leukot Res. 1995:23:125-7.

Authors

K Seibert¹, J Masferrer, Y Zhang, K Leahy, S Hauser, J Gierse, C Koboldt, G Anderson, M Bremer, S Gregory, et al.

Affiliation

¹ G.D. Searle, Monsanto Company, St. Louis, Missouri 63167, USA.

PMID: 7794421

No abstract available

MeSH terms

Analgesia
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Arthritis, Experimental / drug therapy
Cyclooxygenase Inhibitors / pharmacology*
Gene Expression*
Indomethacin / pharmacology
Indomethacin / toxicity
Inflammation / enzymology
Isoenzymes / biosynthesis*
Isoenzymes / metabolism
Organ Specificity
Prostaglandin-Endoperoxide Synthases / biosynthesis*
Prostaglandin-Endoperoxide Synthases / metabolism
Pyrazoles / pharmacology
Pyrazoles / toxicity
RNA, Messenger / analysis
RNA, Messenger / biosynthesis
Rodentia

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase Inhibitors
Isoenzymes
Pyrazoles
RNA, Messenger
1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole
Prostaglandin-Endoperoxide Synthases
Indomethacin