Differential localization of mRNAs encoding dopamine D1 or D2 receptors in cholinergic neurons in the core and shell of the rat nucleus accumbens

A L Jongen-Rêlo; G J Docter; A J Jonker; P Voorn

doi:10.1016/0169-328x(94)00239-b

Differential localization of mRNAs encoding dopamine D1 or D2 receptors in cholinergic neurons in the core and shell of the rat nucleus accumbens

Brain Res Mol Brain Res. 1995 Jan;28(1):169-74. doi: 10.1016/0169-328x(94)00239-b.

Authors

A L Jongen-Rêlo¹, G J Docter, A J Jonker, P Voorn

Affiliation

¹ Graduate School of Neurosciences Amsterdam, Vrije Universiteit, Faculty of Medicine, Department of Anatomy and Embryology, The Netherlands.

PMID: 7707872
DOI: 10.1016/0169-328x(94)00239-b

Abstract

By combining immunocytochemistry for ChAT and in situ hybridization for dopamine D1 or D2 receptor mRNA in the striatum, it was found that (1) the percentage of ChAT/D2 mRNA co-localization is higher in the caudate-putamen than in the shell and core of the nucleus accumbens, (2) in the shell the degree of ChAT/D2 mRNA co-localization is higher rostrally than caudally, and 3) no significant regional differences exist in the degree of co-localization of ChAT and D1 mRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basal Ganglia / metabolism*
Caudate Nucleus / metabolism
Corpus Striatum / metabolism*
Immunohistochemistry
In Situ Hybridization
Nucleus Accumbens / chemistry*
Nucleus Accumbens / metabolism
RNA, Messenger / analysis
RNA, Messenger / genetics*
Rats
Receptors, Dopamine D1 / biosynthesis
Receptors, Dopamine D1 / metabolism*
Receptors, Dopamine D2 / biosynthesis
Receptors, Dopamine D2 / metabolism*

Substances

RNA, Messenger
Receptors, Dopamine D1
Receptors, Dopamine D2