Abstract
An efficient and convenient procedure for the esterification, deformylation, and deacetylation of bile acids is described. This is achieved by the addition of a catalytic amount of methanesulfonic acid or para-toluene sulfonic acid to a solution of bile acid in methanol in the domestic microwave oven. All these reactions were completed in the microwave oven within 1-3 min at 60% power (390 W) and the desired bile acids, namely trihydroxy-5 beta-cholestanoic acid, (23R)-3 alpha,7 alpha,23-trihydroxy-5 beta-cholan-24-oic acid, ursocholic acid and 7-ketolithocholic acid were isolated in 86-94% yield.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylation
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Benzenesulfonates / pharmacology
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Bile Acids and Salts / chemistry*
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Cholic Acid
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Cholic Acids / chemistry
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Esterification
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Indicators and Reagents
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Lithocholic Acid / analogs & derivatives
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Lithocholic Acid / chemistry
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Mesylates / pharmacology
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Microwaves*
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Molecular Structure
Substances
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Benzenesulfonates
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Bile Acids and Salts
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Cholic Acids
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Indicators and Reagents
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Mesylates
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methanesulfonic acid
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7-ketolithocholic acid
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Lithocholic Acid
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Cholic Acid
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ursocholic acid
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cholanic acid
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4-toluenesulfonic acid