Abstract
Lipid microsphere (LM) preparations of corticosteroid, nonsteroid, anti-inflammatory drugs and prostaglandins all showed more potent activity than free drugs. The LM, with a diameter of 0.2 microns, were drug carriers prepared from soybean oil and lecithin, with the drug being incorporated within the LM. This study suggests that the LM is a very promising carrier in a drug delivery system. Future trends in this field are outlined, followed by a discussion of physicochemical properties in the evaluation of novel emulsion delivery systems.
MeSH terms
-
Adsorption
-
Alprostadil / administration & dosage*
-
Alprostadil / chemistry
-
Alprostadil / pharmacology
-
Biological Availability
-
Dexamethasone / administration & dosage
-
Dexamethasone / pharmacology
-
Drug Delivery Systems*
-
Emulsions
-
Flurbiprofen / administration & dosage
-
Flurbiprofen / pharmacology
-
Humans
-
Lipids / chemistry*
-
Microspheres
-
Particle Size
-
Phosphatidylcholines / chemistry
-
Phosphatidylcholines / metabolism
-
Soybean Oil / chemistry
-
Soybean Oil / metabolism
Substances
-
Emulsions
-
Lipids
-
Phosphatidylcholines
-
Flurbiprofen
-
Dexamethasone
-
Soybean Oil
-
Alprostadil