Abstract
Rats self-administered cocaine or received saline during 3 daily 5 h sessions and were euthanized 1 h after the final session. Quantitative in situ hybridization revealed that cocaine self-administration increased levels of preprodynorphin, but not preproenkephalin, c-fos, or zif/268 mRNAs in a patchy pattern in the dorsal striatum. These data demonstrate that the regulation of preprodynorphin gene expression is dissociable from that of c-fos and zif/268 in dorsal striatum following short-term cocaine self-administration.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cocaine / pharmacology*
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Dynorphins / biosynthesis
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Enkephalins / biosynthesis
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Gene Expression / drug effects*
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Image Processing, Computer-Assisted
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In Situ Hybridization
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Male
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Neostriatum / drug effects
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Neostriatum / metabolism*
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / metabolism
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Protein Precursors / biosynthesis
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RNA, Messenger / biosynthesis
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Rats
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Rats, Wistar
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Self Administration
Substances
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Enkephalins
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Protein Precursors
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RNA, Messenger
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pre-prodynorphin
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Dynorphins
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preproenkephalin
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Cocaine