Molecular approaches to amyotrophic lateral sclerosis

Annu Rev Med. 1995:46:133-45. doi: 10.1146/annurev.med.46.1.133.

Abstract

New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.

Publication types

  • Review

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics*
  • Amyotrophic Lateral Sclerosis / mortality
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / mortality
  • Autoimmune Diseases / physiopathology
  • Free Radicals
  • Glutamic Acid / physiology
  • Humans
  • Isoenzymes / genetics
  • Motor Neurons / physiology
  • Mutation
  • Nerve Degeneration / genetics
  • Nerve Degeneration / physiology
  • Phenotype
  • Superoxide Dismutase / genetics
  • Survival Rate

Substances

  • Free Radicals
  • Isoenzymes
  • Glutamic Acid
  • Superoxide Dismutase