Abstract
In these studies blood pressure responses to intracerebroventricular (i.c.v.) infusions were recorded in anesthetized rats. NO donors caused a fall in blood pressure, whereas L-NAME, which blocks the enzyme (NOS) that produces NO, caused a rise in blood pressure. Calcium, i.c.v., stimulates NOS to lower blood pressure. The depressor action of NO is reduced by blocking the action of cGMP. This central NO/cGMP system is tonically active to maintain blood pressure at a normal level.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Oxidoreductases / antagonists & inhibitors
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Animals
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Arginine / administration & dosage
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Arginine / analogs & derivatives*
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Arginine / pharmacology
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Blood Pressure / drug effects*
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Calcium Chloride / administration & dosage
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Calcium Chloride / pharmacology*
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Cerebral Ventricles / drug effects
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Cerebral Ventricles / physiology*
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Cyclic GMP / analogs & derivatives
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Cyclic GMP / pharmacology
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Cyclic GMP / physiology
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Dose-Response Relationship, Drug
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Injections, Intraventricular
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Male
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NG-Nitroarginine Methyl Ester
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Nitric Oxide / physiology*
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Nitric Oxide Synthase
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Rats
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Rats, Inbred WKY
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Thionucleotides / pharmacology
Substances
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Thionucleotides
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8-bromoguanosino-3',5'-cyclic monophosphorothioate
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Nitric Oxide
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Arginine
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases
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Cyclic GMP
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Calcium Chloride
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NG-Nitroarginine Methyl Ester