Bradykinin induces generation of reactive oxygen species in bovine aortic endothelial cells

Res Commun Chem Pathol Pharmacol. 1994 Jun;84(3):301-14.

Abstract

We investigated the effects of bradykinin on intracellular oxidative stress in bovine aortic endothelial cells using a hydroperoxide-sensitive fluorescent dye, 2',7'-dichlorofluorescein (DCFH), and a laser scanning confocal microscope. Bradykinin induced an immediate increase in intracellular Ca2+ concentration, and stimulated the oxidation of DCFH in cultured endothelial cells. This bradykinin-induced oxidation of DCFH was inhibited by pretreatment with N-(2-mercaptopropionyl)-glycine (MPG) and 1,3-dimethyl-thiourea (DMTU), scavengers of hydroxyl radical, and the removal of extracellular Ca2+ but was unaffected by NG-nitro-L-arginine or NG-monomethyl-L-arginine, both inhibitors of nitric oxide (NO) synthase. On the other hand, pretreatment with indomethacin and aspirin, inhibitors of cyclooxygenase, inhibited bradykinin-induced oxidation of DCFH. These findings suggest that bradykinin increases intracellular Ca2+ and stimulates the generation of hydroxyl radical-like reactive oxygen species (scavenged by MPG or DMTU) via the cyclooxygenase pathway but not via the reaction of NO and superoxide anion.

MeSH terms

  • Amino Acid Oxidoreductases / antagonists & inhibitors
  • Animals
  • Aorta
  • Bradykinin / antagonists & inhibitors
  • Bradykinin / pharmacology*
  • Calcium / metabolism
  • Cattle
  • Cells, Cultured
  • Cyclooxygenase Inhibitors / pharmacology
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / metabolism
  • Fluoresceins / metabolism
  • Free Radical Scavengers
  • Hydroxyl Radical / metabolism
  • Microscopy, Fluorescence
  • Nitric Oxide Synthase
  • Oxidative Stress / drug effects
  • Reactive Oxygen Species / metabolism*

Substances

  • Cyclooxygenase Inhibitors
  • Fluoresceins
  • Free Radical Scavengers
  • Reactive Oxygen Species
  • Hydroxyl Radical
  • 2',7'-dichlorofluorescein
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases
  • Bradykinin
  • Calcium