Abstract
The effect of angiotensin (ANG) IV on CBF after experimental subarachnoid hemorrhage (SAH) was studied in rats using laser-Doppler flowmetry. ANG IV (1 microgram/kg/min i.v.) or saline treatments were started 20 min after SAH. ANG IV increased CBF (from 45 to 84% of baseline) by 60 min. In the saline group, CBF remained low (51%). Pretreatment with the specific ANG II antagonist Sar1, Ile8-ANG II did not antagonize ANG IV. Determination of nitric oxide synthase (NOS) activity in vitro or inhibition of NOS in vivo did not support a role for NO in the action of ANG IV.
MeSH terms
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Amino Acid Oxidoreductases / metabolism
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Angiotensin II / analogs & derivatives*
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Angiotensin II / antagonists & inhibitors
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Angiotensin II / pharmacology
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Animals
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Arginine / analogs & derivatives
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Arginine / pharmacology
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Blood Pressure / drug effects
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Cerebral Arteries / enzymology
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Cerebrovascular Circulation / drug effects*
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Male
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NG-Nitroarginine Methyl Ester
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide Synthase
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Rats
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Rats, Sprague-Dawley
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Subarachnoid Hemorrhage / physiopathology*
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Time Factors
Substances
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Angiotensin II
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angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-
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Nitric Oxide
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Arginine
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases
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NG-Nitroarginine Methyl Ester