1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist

J Med Chem. 1995 Nov 10;38(23):4634-6. doi: 10.1021/jm00023a002.
No abstract available

MeSH terms

  • Animals
  • Antidiuretic Hormone Receptor Antagonists
  • Benzoxazines
  • Biological Availability
  • Female
  • Humans
  • Kinetics
  • Molecular Structure
  • Obstetric Labor, Premature / drug therapy
  • Oxazines / chemistry
  • Oxazines / pharmacokinetics
  • Oxazines / pharmacology*
  • Oxytocin / antagonists & inhibitors*
  • Piperidines / chemistry
  • Piperidines / pharmacokinetics
  • Piperidines / pharmacology*
  • Pregnancy
  • Rats
  • Receptors, Oxytocin / metabolism
  • Receptors, Vasopressin / metabolism
  • Uterine Contraction / drug effects

Substances

  • Antidiuretic Hormone Receptor Antagonists
  • Benzoxazines
  • L 371257
  • Oxazines
  • Piperidines
  • Receptors, Oxytocin
  • Receptors, Vasopressin
  • Oxytocin