Embryotoxicity and teratogenicity of the anthracycline antibiotic carminomycin in mice

Res Commun Chem Pathol Pharmacol. 1980 Jun;28(3):497-504.

Abstract

Carminomycin, a new antitumor anthracycline antibiotic, has embryolethal, embryotoxic and teratogenic effects during early postimplantation stages of development in mice. These effects depend on the dose and route of administration and the gestational age of the exposed embryos.

MeSH terms

  • Abnormalities, Drug-Induced / pathology
  • Animals
  • Carubicin / toxicity*
  • Daunorubicin / analogs & derivatives*
  • Embryo, Mammalian / drug effects*
  • Female
  • Fetus / drug effects
  • Male
  • Mice
  • Teratogens*

Substances

  • Teratogens
  • Carubicin
  • Daunorubicin