Selective inactivation of cytochrome P-450 isozymes by suicide substrates

Arch Biochem Biophys. 1981 Sep;210(2):717-28. doi: 10.1016/0003-9861(81)90239-3.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Binding Sites
  • Cytochrome P-450 Enzyme Inhibitors*
  • Isoenzymes / antagonists & inhibitors*
  • Kinetics
  • Male
  • Methylcholanthrene / pharmacology
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology*
  • Phenobarbital / pharmacology
  • Protein Binding
  • Rats
  • Rats, Inbred Strains
  • Substrate Specificity

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Isoenzymes
  • Methylcholanthrene
  • Phenobarbital