Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus

G Albers-Schönberg; H Joshua; M B Lopez; O D Hensens; J P Springer; J Chen; S Ostrove; C H Hoffman; A W Alberts; A A Patchett

doi:10.7164/antibiotics.34.507

Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus

J Antibiot (Tokyo). 1981 May;34(5):507-12. doi: 10.7164/antibiotics.34.507.

Authors

G Albers-Schönberg, H Joshua, M B Lopez, O D Hensens, J P Springer, J Chen, S Ostrove, C H Hoffman, A W Alberts, A A Patchett

PMID: 7275832
DOI: 10.7164/antibiotics.34.507

Abstract

A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA reductase, inhibition of sterol synthesis in cell cultures, and inhibition of cholesterol synthesis in vivo in rats.

MeSH terms

Animals
Anticholesteremic Agents / metabolism*
Aspergillus / metabolism*
Cholesterol / biosynthesis
Desmosterol / biosynthesis
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
In Vitro Techniques
Lovastatin* / analogs & derivatives*
Molecular Conformation
Naphthalenes / biosynthesis*
Naphthalenes / pharmacology
Rats

Substances

Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Naphthalenes
Desmosterol
dihydromevinolin
Cholesterol
Lovastatin