Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase

Biochem Pharmacol. 1981 Feb 1;30(3):247-57. doi: 10.1016/0006-2952(81)90085-x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Binding Sites
  • Chemical Phenomena
  • Chemistry
  • Deoxyuracil Nucleotides / metabolism*
  • Fluorodeoxyuridylate / metabolism*
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Leukemia, Lymphoid / enzymology
  • Methyltransferases / metabolism*
  • Models, Biological
  • Protein Binding
  • Thymidylate Synthase / metabolism*

Substances

  • Deoxyuracil Nucleotides
  • Fluorodeoxyuridylate
  • Methyltransferases
  • Thymidylate Synthase