Abstract
The effects of morphine and a potent enkephalin analogue on spontaneous locomotion have been compared in mice. In doses of 3-10 mg/kg SC both compounds induced a brief reduction of motor activity followed by a period of behavioral hyperactivity. Similar receptorial mechanisms are suggested in mediation of their motor effects.
MeSH terms
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Animals
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Dose-Response Relationship, Drug
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Endorphins / pharmacology*
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Enkephalin, Methionine* / analogs & derivatives*
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Enkephalins / pharmacology*
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Male
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Mice
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Morphine / pharmacology*
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Motor Activity / drug effects*
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Time Factors
Substances
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Endorphins
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Enkephalins
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Enkephalin, Methionine
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enkephalin, Met(2)-ProNH2(5)-
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Morphine