Biphasic effects of a potent enkephalin analogue (D-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice

Psychopharmacology (Berl). 1980;71(3):299-301. doi: 10.1007/BF00433065.

Abstract

The effects of morphine and a potent enkephalin analogue on spontaneous locomotion have been compared in mice. In doses of 3-10 mg/kg SC both compounds induced a brief reduction of motor activity followed by a period of behavioral hyperactivity. Similar receptorial mechanisms are suggested in mediation of their motor effects.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Endorphins / pharmacology*
  • Enkephalin, Methionine* / analogs & derivatives*
  • Enkephalins / pharmacology*
  • Male
  • Mice
  • Morphine / pharmacology*
  • Motor Activity / drug effects*
  • Time Factors

Substances

  • Endorphins
  • Enkephalins
  • Enkephalin, Methionine
  • enkephalin, Met(2)-ProNH2(5)-
  • Morphine