Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency

A Ganer; B Knobel; C H Fryd; E A Rachmilewitz

Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency

Isr J Med Sci. 1981 Aug;17(8):703-4.

Authors

A Ganer, B Knobel, C H Fryd, E A Rachmilewitz

PMID: 6765904

Abstract

Methemoglobinemia and hemolysis are well-known side effects after using high doses of dapsone (4,4'-diaminodiphenylsulfone). Their occurrence after low doses of the drug, and subsequent investigation, revealed the presence of hemoglobin Hasharon, and low content of NADH-dependent methemoglobin reductase in five members of an East European ashkenazic Jewish family.

Publication types

Case Reports

MeSH terms

Adult
Cytochrome-B(5) Reductase / deficiency*
Dapsone / adverse effects*
Hemoglobinopathies / blood*
Hemoglobinopathies / enzymology
Hemoglobins, Abnormal*
Hemolysis / drug effects*
Humans
Male
Methemoglobinemia / chemically induced*
NADH, NADPH Oxidoreductases / deficiency*

Substances

Hemoglobins, Abnormal
hemoglobin Sealy
Dapsone
NADH, NADPH Oxidoreductases
Cytochrome-B(5) Reductase