Abstract
1. The association of antagonism of apomorphine-induced climbing with potentiation of apomorphine-induced gnawing in mice has been suggested as a means to detect "atypical" neuroleptics. 2. Clozapine, many compounds with central anticholinergic activity and propranolol have been demonstrated to possess this profile of activities. 3. Pharmacological manipulations with cholinomimetics suggest a cholinergic modulation of the gnawing behavior induced by apomorphine. 4. The observations with propranolol cannot be explained either by a cholinergic link nor by beta-adrenergic antagonism.
MeSH terms
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Animals
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Antidepressive Agents / pharmacology
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Apomorphine / pharmacology*
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Dose-Response Relationship, Drug
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Exploratory Behavior / drug effects
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Histamine Antagonists / pharmacology
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Humans
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Male
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Mastication / drug effects*
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Mice
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Mice, Inbred ICR
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Motor Activity / drug effects
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Muscle Relaxants, Central / pharmacology
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Parasympatholytics / pharmacology
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Parasympathomimetics / pharmacology
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Propranolol / pharmacology
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Receptors, Dopamine / drug effects
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Receptors, Muscarinic / drug effects
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Stereotyped Behavior / drug effects*
Substances
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Antidepressive Agents
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Histamine Antagonists
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Muscle Relaxants, Central
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Parasympatholytics
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Parasympathomimetics
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Receptors, Dopamine
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Receptors, Muscarinic
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Propranolol
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Apomorphine