Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys

Eur J Pharmacol. 1984 Oct 30;106(1):209-10. doi: 10.1016/0014-2999(84)90700-3.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Caudate Nucleus / drug effects*
  • Caudate Nucleus / metabolism
  • Dopamine / metabolism
  • Female
  • Homovanillic Acid / metabolism
  • Macaca fascicularis
  • Pargyline / pharmacology
  • Pargyline / therapeutic use*
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / prevention & control
  • Phenethylamines / therapeutic use*
  • Pyridines / antagonists & inhibitors
  • Pyridines / toxicity*
  • Selegiline / pharmacology
  • Selegiline / therapeutic use*

Substances

  • Phenethylamines
  • Pyridines
  • Selegiline
  • Pargyline
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Dopamine
  • Homovanillic Acid