Abstract
Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Anxiety Agents*
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Benzodiazepines*
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Benzodiazepinones / administration & dosage
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Benzodiazepinones / analysis
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Benzodiazepinones / metabolism*
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Brain / metabolism*
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Brain Chemistry
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Chlordiazepoxide / administration & dosage
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Chlordiazepoxide / analogs & derivatives
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Chlordiazepoxide / analysis
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Flumazenil
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Half-Life
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Kinetics
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Male
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Rats
Substances
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Anti-Anxiety Agents
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Benzodiazepinones
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Benzodiazepines
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Flumazenil
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Chlordiazepoxide
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N-demethylchlordiazepoxide
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demoxepam