Abstract
Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arachidonic Acid
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Arachidonic Acids / metabolism
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Arachidonic Acids / pharmacology*
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Arginine / pharmacology
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Glucagon / metabolism*
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Glucose / pharmacology
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Insulin / metabolism*
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Insulin Secretion
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Islets of Langerhans / drug effects
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Islets of Langerhans / metabolism*
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Kinetics
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Male
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Rats
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Rats, Inbred Strains
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Structure-Activity Relationship
Substances
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Arachidonic Acids
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Insulin
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Arachidonic Acid
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Glucagon
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Arginine
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Glucose